FCGR2A, FCGR3A polymorphisms and therapeutic efficacy of anti-EGFR monoclonal antibody in metastatic colorectal cancer

Anti-EGFR monoclonal antibodies (mAb) such as cetuximab, panitumumab are one kind of efficacious targeted drugs in treatment of metastatic colorectal cancer (mCRC). However, only a small proportion of patients harbored wild-KRAS genotype can benefit from it. We hypothesized that personal genetic het...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Ying, Hou-Qun, Wang, Feng, Chen, Xiao-Lin, He, Bang-Shun, Pan, Yu-Qin, Chen, Jie, Liu, Xian, Cao, Wei-Jun, Peng, Hong-Xin, Lin, Kang, Wang, Shu-Kui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695045/
https://ncbi.nlm.nih.gov/pubmed/26363448
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