Phosphorylation of apoptosis repressor with caspase recruitment domain by protein kinase CK2 contributes to chemotherapy resistance by inhibiting doxorubicin induced apoptosis

The development of cancer resistance to chemotherapy is the major obstacle to cancer therapy. Here, we identified that the phosphorylation of apoptosis repressor with caspase recruitment domain (ARC) at threonine 149 was essential to inhibit doxorubicin (DOX) induced apoptosis and mitochondrial fiss...

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Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Wang, Jianxun, Feng, Chang, He, Yuqi, Ding, Wei, Sheng, Jianqiu, Arshad, Muhammad, Zhang, Xiaojie, Li, Peifeng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2015
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695019/
https://ncbi.nlm.nih.gov/pubmed/26172393
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