Phosphorylation of apoptosis repressor with caspase recruitment domain by protein kinase CK2 contributes to chemotherapy resistance by inhibiting doxorubicin induced apoptosis

The development of cancer resistance to chemotherapy is the major obstacle to cancer therapy. Here, we identified that the phosphorylation of apoptosis repressor with caspase recruitment domain (ARC) at threonine 149 was essential to inhibit doxorubicin (DOX) induced apoptosis and mitochondrial fiss...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Wang, Jianxun, Feng, Chang, He, Yuqi, Ding, Wei, Sheng, Jianqiu, Arshad, Muhammad, Zhang, Xiaojie, Li, Peifeng
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695019/
https://ncbi.nlm.nih.gov/pubmed/26172393
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