Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells

Cisplatin-DNA adducts act as strong decoys for the Upstream Binding Factor UBF (UBTF) and have been shown to inhibit transcription of the ribosomal RNA genes by RNA polymerase I. However, it is unclear if this plays a significant role in the chemotherapeutic activity of cis- or carboplatin. We find...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hamdane, Nourdine, Herdman, Chelsea, Mars, Jean-Clement, Stefanovsky, Victor, Tremblay, Michel G., Moss, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695006/
https://ncbi.nlm.nih.gov/pubmed/26317157
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