Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts

miR-21 is an oncogenic microRNA (miRNA) with an emerging role as therapeutic target in human malignancies, including multiple myeloma (MM). Here we investigated whether miR-21 is involved in MM-related bone disease (BD). We found that miR-21 expression is dramatically enhanced, while osteoprotegerin...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Pitari, Maria Rita, Rossi, Marco, Amodio, Nicola, Botta, Cirino, Morelli, Eugenio, Federico, Cinzia, Gullà, Annamaria, Caracciolo, Daniele, Di Martino, Maria Teresa, Arbitrio, Mariamena, Giordano, Antonio, Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694994/
https://ncbi.nlm.nih.gov/pubmed/26160841
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