The sum of gains and losses of genes encoding the protein tyrosine kinase targets predicts response to multi-kinase inhibitor treatment: Characterization, validation, and prognostic value

Validated predictive biomarkers for multi-tyrosine kinase inhibitors (MTKI) efficacy are lacking. We hypothesized that interindividual response variability is partially dependent on somatic DNA copy number alterations (SCNAs), particularly those of genes encoding the protein tyrosines targeted by MT...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Jiang, Xiaojun, Pissaloux, Daniel, De La Fouchardiere, Christelle, Desseigne, Françoise, Wang, Qing, Attignon, Valery, Fondrevelle, Marie-Eve, De La Fouchardiere, Arnaud, Perol, Maurice, Cassier, Philippe, Seigne, Christelle, Perol, David, Coquard, Isabelle Ray, Meeus, Pierre, Fayette, Jerome, Flechon, Aude, Le Cesne, Axel, Penel, Nicolas, Tredan, Olivier, Blay, Jean-Yves
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694909/
https://ncbi.nlm.nih.gov/pubmed/26317543
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