Folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinoma

Patients with hepatocellular carcinoma (HCC) are prone to folate deficiency (FD). Here we showed that, in cell line-specific manner, FD caused resistance to FD-induced oxidative stress and multi-drug resistance (MDR). This resistance was due to upregulation of glucose-regulated protein 78 (GRP78) an...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Ho, Chun-Te, Shang, Hung-Sheng, Chang, Jin-Biou, Liu, Jun-Jen, Liu, Tsan-Zon
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694889/
https://ncbi.nlm.nih.gov/pubmed/26327128
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