Understanding of tolerance in TRAIL-induced apoptosis and cancelation of its machinery by α-mangostin, a xanthone derivative

Tumor necrosis-factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF-superfamily that selectively induces apoptosis through death receptors (DRs) 4 and/or 5 in cancer cells. These receptors are expressed on the cancer cell surface, without affecting normal cells. Unfortunatel...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Kumazaki, Minami, Shinohara, Haruka, Taniguchi, Kohei, Ueda, Hiroshi, Nishi, Mayuko, Ryo, Akihide, Akao, Yukihiro
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694869/
https://ncbi.nlm.nih.gov/pubmed/26304927
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