Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARα protein degradation

Arsenic trioxide (As(2)O(3)) is one of the most effective therapeutic agents used for patients with acute promyelocytic leukemia (APL). The probable explanation for As(2)O(3)-induced cell differentiation is the direct targeting of PML-RARα oncoprotein by As(2)O(3), which results in initiation of PML...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Qian Qian, Zhou, Xin Yi, Zhang, Yan Fang, Bu, Na, Zhou, Jin, Cao, Feng Lin, Naranmandura, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694856/
https://ncbi.nlm.nih.gov/pubmed/26213848
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