Targeting endosialin/CD248 through antibody-mediated internalization results in impaired pericyte maturation and dysfunctional tumor microvasculature

Over-expression of endosialin/CD248 (herein referred to as CD248) has been associated with increased tumor microvasculature in various tissue origins which makes it an attractive anti-angiogenic target. In an effort to target CD248, we have generated a human CD248 knock-in mouse line and MORAb-004,...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Rybinski, Katherine, Imtiyaz, Hongxia Z., Mittica, Barrie, Drozdowski, Brian, Fulmer, James, Furuuchi, Keiji, Fernando, Shawn, Henry, Marianne, Chao, Qimin, Kline, Brad, Albone, Earl, Wustner, Jason, Lin, JianMin, Nicolaides, Nicholas C., Grasso, Luigi, Zhou, Yuhong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694842/
https://ncbi.nlm.nih.gov/pubmed/26327620
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