An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

The human lymphoblastoid MT1 B-cell line was previously isolated as one of a series of mutant cells able to survive the cytotoxic effects of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). MT1 cells nevertheless remain sensitive to mutagenesis by MNNG and display a mutator phenotype. These phenotypes h...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Kat, A, Thilly, W G, Fang, W H, Longley, M J, Li, G M, Modrich, P
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1993
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46944/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8341649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.14.6424
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