An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

The human lymphoblastoid MT1 B-cell line was previously isolated as one of a series of mutant cells able to survive the cytotoxic effects of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). MT1 cells nevertheless remain sensitive to mutagenesis by MNNG and display a mutator phenotype. These phenoty...

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Main Authors: Kat, A, Thilly, W G, Fang, W H, Longley, M J, Li, G M, Modrich, P
Format: Artigo
Jezik:Inglês
Izdano: 1993
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC46944/
https://ncbi.nlm.nih.gov/pubmed/8341649
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