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An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

The human lymphoblastoid MT1 B-cell line was previously isolated as one of a series of mutant cells able to survive the cytotoxic effects of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). MT1 cells nevertheless remain sensitive to mutagenesis by MNNG and display a mutator phenotype. These phenotypes h...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kat, A, Thilly, W G, Fang, W H, Longley, M J, Li, G M, Modrich, P
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46944/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8341649/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.14.6424
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