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The law of mass action and the pharmacological concentration–effect curve: resolving the paradox of apparently non‐dose‐related adverse drug reactions

BACKGROUND: Adverse drug reactions are sometimes described as being ‘non‐dose‐related’ because no relationship has been found between increasing doses and either the intensity of the response or the proportion of individuals in whom the response occurs; furthermore, hypersensitivity reactions are of...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: Aronson, Jeffrey K., Ferner, Robin E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4693576/
https://ncbi.nlm.nih.gov/pubmed/26119837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12706
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