DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions.

Plasmid DNA was gamma-irradiated or treated with H2O2 in the presence of Cu2+ to generate oxygen free radical-induced lesions. Open circular DNA molecules were removed by ethidium bromide/CsCl density gradient centrifugation. The closed circular DNA fraction was treated with the Escherichia coli rea...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Satoh, M S, Jones, C J, Wood, R D, Lindahl, T
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46923/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8327515/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.13.6335
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