Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression

Rare endothelial cells in the aorta-gonad-mesonephros (AGM) transition into hematopoietic stem cells (HSCs) during embryonic development. Lineage tracing experiments indicate that HSCs emerge from cadherin 5 (Cdh5; vascular endothelial–cadherin)(+) endothelial precursors, and isolated populations of...

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Udgivet i:Blood
Main Authors: Anderson, Heidi, Patch, Taylor C., Reddy, Pavankumar N. G., Hagedorn, Elliott J., Kim, Peter G., Soltis, Kathleen A., Chen, Michael J., Tamplin, Owen J., Frye, Maike, MacLean, Glenn A., Hübner, Kathleen, Bauer, Daniel E., Kanki, John P., Vogin, Guillaume, Huston, Nicholas C., Nguyen, Minh, Fujiwara, Yuko, Paw, Barry H., Vestweber, Dietmar, Zon, Leonard I., Orkin, Stuart H., Daley, George Q., Shah, Dhvanit I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2015
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692141/
https://ncbi.nlm.nih.gov/pubmed/26385351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-07-659276
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