Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis

Cytotoxic T lymphocytes (CTLs) are highly effective serial killers capable of destroying virally infected and cancerous targets by polarized release from secretory lysosomes. Upon target contact, the CTL centrosome rapidly moves to the immunological synapse, focusing microtubule-directed release at...

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Publicado en:Curr Biol
Main Authors: Stinchcombe, Jane C., Randzavola, Lyra O., Angus, Karen L., Mantell, Judith M., Verkade, Paul, Griffiths, Gillian M.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691242/
https://ncbi.nlm.nih.gov/pubmed/26670998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2015.10.028
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