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Induced Dipole–Dipole Interactions Influence the Unfolding Pathways of Wild-Type and Mutant Amyloid β-Peptides

[Image: see text] Amyloid-forming proteins undergo a structural transition from α-helical to disordered conformations and, ultimately, cross-β fibrils. The unfolding and aggregation of the amyloid β-peptide (Aβ) have been implicated in the development and progression of Alzheimer’s disease (AD) and...

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Vydáno v:J Phys Chem B
Hlavní autoři: Lemkul, Justin A., Huang, Jing, MacKerell, Alexander D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2015
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4690986/
https://ncbi.nlm.nih.gov/pubmed/26629591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.5b09978
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