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NG2 proteoglycan ablation reduces foam cell formation and atherogenesis via decreased low-density lipoprotein retention by synthetic smooth muscle cells

OBJECTIVES: Obesity and hyperlipidemia are critical risk factors for atherosclerosis. Since ablation of NG2 proteoglycan in mice leads to hyperlipidemia and obesity, we investigated the impact of NG2 ablation on atherosclerosis in ApoE null mice. APPROACH AND RESULTS: Immunostaining indicates that N...

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Bibliografiske detaljer
Udgivet i:Arterioscler Thromb Vasc Biol
Main Authors: She, Zhi-Gang, Chang, Yunchao, Pang, Hong-Bo, Han, Wenlong, Chen, Hou-Zao, Smith, Jeffrey W., Stallcup, William B.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4690796/
https://ncbi.nlm.nih.gov/pubmed/26543095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.306074
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