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CIGARETTE SMOKE INDUCES PROTEASOMAL-MEDIATED DEGRADATION OF DNA METHYLTRANSFERASES AND METHYL CpG-/CpG DOMAIN-BINDING PROTEINS IN EMBRYONIC OROFACIAL CELLS

Orofacial clefts, the most prevalent of developmental anomalies, occur with a frequency of 1 in 700 live births. Maternal cigarette smoking during pregnancy represents a risk factor for having a child with a cleft lip and/or cleft palate. Using primary cultures of first branchial arch-derived cells...

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Pubblicato in:Reprod Toxicol
Autori principali: Mukhopadhyay, Partha, Greene, Robert M., Pisano, M. Michele
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4690750/
https://ncbi.nlm.nih.gov/pubmed/26482727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reprotox.2015.10.009
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