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Mutations in the Voltage Sensors of Domains I and II of Na(v)1.5 that are Associated with Arrhythmias and Dilated Cardiomyopathy Generate Gating Pore Currents

Voltage gated sodium channels (Na(v)) are transmembrane proteins responsible for action potential initiation. Mutations mainly located in the voltage sensor domain (VSD) of Na(v)1.5, the cardiac sodium channel, have been associated with the development of arrhythmias combined with dilated cardiomyop...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Front Pharmacol
Κύριοι συγγραφείς: Moreau, Adrien, Gosselin-Badaroudine, Pascal, Boutjdir, Mohamed, Chahine, Mohamed
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Frontiers Media S.A. 2015
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689871/
https://ncbi.nlm.nih.gov/pubmed/26733869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00301
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