Mutations in the Voltage Sensors of Domains I and II of Na(v)1.5 that are Associated with Arrhythmias and Dilated Cardiomyopathy Generate Gating Pore Currents

Voltage gated sodium channels (Na(v)) are transmembrane proteins responsible for action potential initiation. Mutations mainly located in the voltage sensor domain (VSD) of Na(v)1.5, the cardiac sodium channel, have been associated with the development of arrhythmias combined with dilated cardiomyop...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Main Authors: Moreau, Adrien, Gosselin-Badaroudine, Pascal, Boutjdir, Mohamed, Chahine, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2015
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689871/
https://ncbi.nlm.nih.gov/pubmed/26733869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00301
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