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Mutations in the Voltage Sensors of Domains I and II of Na(v)1.5 that are Associated with Arrhythmias and Dilated Cardiomyopathy Generate Gating Pore Currents

Voltage gated sodium channels (Na(v)) are transmembrane proteins responsible for action potential initiation. Mutations mainly located in the voltage sensor domain (VSD) of Na(v)1.5, the cardiac sodium channel, have been associated with the development of arrhythmias combined with dilated cardiomyop...

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Dades bibliogràfiques
Publicat a:Front Pharmacol
Autors principals: Moreau, Adrien, Gosselin-Badaroudine, Pascal, Boutjdir, Mohamed, Chahine, Mohamed
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689871/
https://ncbi.nlm.nih.gov/pubmed/26733869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00301
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