Human G109E-Inhibitor-1 Impairs Cardiac Function and Promotes Arrhythmias

A hallmark of human and experimental heart failure is deficient sarcoplasmic reticulum (SR) Ca-uptake reflecting impaired contractile function. This is at least partially attributed to dephosphorylation of phospholamban by increased protein phosphatase 1 (PP1) activity. Indeed inhibition of PP1 by t...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Haghighi, Kobra, Pritchard, Tracy J., Liu, Guan-Sheng, Singh, Vivek P., Bidwell, Philip, Lam, Chi Keung, Vafiadaki, Elizabeth, Das, Parthib, Ma, Jianyong, Kunduri, Swati, Sanoudou, Despina, Florea, Stela, Vanderbilt, Erica, Wang, Hong-Shang, Rubinstein, Jack, Hajjar, Roger J., Kranias, Evangelia G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689614/
https://ncbi.nlm.nih.gov/pubmed/26455482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.10.004
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