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Trm9-Catalyzed tRNA Modifications Regulate Global Protein Expression by Codon-Biased Translation

Post-transcriptional modifications of transfer RNAs (tRNAs) have long been recognized to play crucial roles in regulating the rate and fidelity of translation. However, the extent to which they determine global protein production remains poorly understood. Here we use quantitative proteomics to show...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Deng, Wenjun, Babu, I. Ramesh, Su, Dan, Yin, Shanye, Begley, Thomas J., Dedon, Peter C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689569/
https://ncbi.nlm.nih.gov/pubmed/26670883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005706
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