Increased Cortical Synaptic Activation of TrkB and Downstream Signaling Markers in a Mouse Model of Down Syndrome

Down Syndrome (DS), trisomy 21, is characterized by synaptic abnormalities and cognitive deficits throughout the lifespan and with development of Alzheimer’s disease (AD) neuropathology and progressive cognitive decline in adults. Synaptic abnormalities are also present in the Ts65Dn mouse model of...

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Publicado en:Neurobiol Dis
Main Authors: Nosheny, RL, Belichenko, PV, Busse, BL, Weissmiller, AM, Dang, V, Das, D, Fahimi, A, Salehi, A, Smith, SJ, Mobley, WC
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689307/
https://ncbi.nlm.nih.gov/pubmed/25753471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.02.022
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