Selective interleukin-1 receptor–associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy

Pathological activation of the Toll-like receptor signaling adaptor protein MYD88 underlies many autoimmune and inflammatory disease states. In the activated B cell–like (ABC) subtype of diffuse large B cell lymphoma (DLBCL), the oncogenic MYD88 L265P mutation occurs in 29% of cases, making it the m...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Kelly, Priscilla N., Romero, Donna L., Yang, Yibin, Shaffer, Arthur L., Chaudhary, Divya, Robinson, Shaughnessy, Miao, Wenyan, Rui, Lixin, Westlin, William F., Kapeller, Rosana, Staudt, Louis M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689168/
https://ncbi.nlm.nih.gov/pubmed/26621451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151074
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