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Targeting pathological B cell receptor signalling in lymphoid malignancies

Signalling through the B cell receptor (BCR) is central to the development and maintenance of B cells. In light of the numerous proliferative and survival pathways activated downstream of the BCR, it comes as no surprise that malignant B cells would co-opt this receptor to promote their own growth a...

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Détails bibliographiques
Publié dans:Nat Rev Drug Discov
Auteurs principaux: Young, Ryan M., Staudt, Louis M.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595252/
https://ncbi.nlm.nih.gov/pubmed/23449308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd3937
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