Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation

T cell (or transmembrane) immunoglobulin and mucin domain protein 3 (Tim-3) has attracted significant attention as a novel immune checkpoint receptor (ICR) on chronically stimulated, often dysfunctional, T cells. Antibodies to Tim-3 can enhance antiviral and antitumor immune responses. Tim-3 is also...

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Publicado en:J Exp Med
Autores principales: Phong, Binh L., Avery, Lyndsay, Sumpter, Tina L., Gorman, Jacob V., Watkins, Simon C., Colgan, John D., Kane, Lawrence P.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689164/
https://ncbi.nlm.nih.gov/pubmed/26598760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150388
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