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Targeting KRAS-mutant non-small cell lung cancer: challenges and opportunities

Oncogenic mutations in Kirsten rat sarcoma viral oncogene homolog (KRAS) occur in 15%–30% of non-small cell lung cancer (NSCLC). However, despite decades of intensive research, there is still no direct KRAS inhibitor with clinically proven efficacy. Considering its association with poor treatment re...

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Detalles Bibliográficos
Publicado en:Acta Biochim Biophys Sin (Shanghai)
Autores principales: Zhang, Jun, Park, Dongkyoo, Shin, Dong M., Deng, Xingming
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689161/
https://ncbi.nlm.nih.gov/pubmed/26578706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/abbs/gmv118
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