Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current I(f): Novel electrophysiological insights and therapeutic potential

BACKGROUND: Bradycardic agents are of interest for the treatment of ischemic heart disease and heart failure, as heart rate is an important determinant of myocardial oxygen consumption. OBJECTIVES: The purpose of this study was to investigate the propensity of hydroxychloroquine (HCQ) to cause brady...

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Vydáno v:Heart Rhythm
Hlavní autoři: Capel, Rebecca A., Herring, Neil, Kalla, Manish, Yavari, Arash, Mirams, Gary R., Douglas, Gillian, Bub, Gil, Channon, Keith, Paterson, David J., Terrar, Derek A., Burton, Rebecca-Ann B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689153/
https://ncbi.nlm.nih.gov/pubmed/26025323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2015.05.027
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