Codon 249 mutations of p53 gene in development of hepatocellular carcinoma

AIM: To investigate the mechanisms of codon 249 mutation of p53 gene in the formation of hepatocellular carcinoma (HCC). METHODS: Codon 249 mutation accompanied by loss of heterozygosity (LOH) and its effect on translation and transcription were studied using SSCP, IHC and RT-PCR/slot hybridization....

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Bibliographic Details
Published in:World J Gastroenterol
Main Authors: Peng, Xiao-Mou, Peng, Wen-Wei, Yao, Ji-Lu
Format: Artigo
Language:Inglês
Published: Baishideng Publishing Group Inc 1998
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688632/
https://ncbi.nlm.nih.gov/pubmed/11819254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v4.i2.125
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