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Codon 249 mutations of p53 gene in development of hepatocellular carcinoma
AIM: To investigate the mechanisms of codon 249 mutation of p53 gene in the formation of hepatocellular carcinoma (HCC). METHODS: Codon 249 mutation accompanied by loss of heterozygosity (LOH) and its effect on translation and transcription were studied using SSCP, IHC and RT-PCR/slot hybridization....
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| Veröffentlicht in: | World J Gastroenterol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Baishideng Publishing Group Inc
1998
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4688632/ https://ncbi.nlm.nih.gov/pubmed/11819254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v4.i2.125 |
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