Lipocalin-2 ensures host defense against Salmonella Typhimurium by controlling macrophage iron homeostasis and immune response

Lipocalin-2 (Lcn2) is an innate immune peptide with pleiotropic effects. Lcn2 binds iron-laden bacterial siderophores, chemo-attracts neutrophils and has immunomodulatory and apoptosis-regulating effects. In this study we show that upon infection with Salmonella enterica serovar Typhimurium, Lcn2 pr...

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Publicat a:Eur J Immunol
Autors principals: Nairz, Manfred, Schroll, Andrea, Haschka, David, Dichtl, Stefanie, Sonnweber, Thomas, Theurl, Igor, Theurl, Milan, Lindner, Ewald, Demetz, Egon, Aβhoff, Malte, Bellmann-Weiler, Rosa, Müller, Raphael, Gerner, Romana R., Moschen, Alexander R., Baumgartner, Nadja, Moser, Patrizia L., Talasz, Heribert, Tilg, Herbert, Fang, Ferric C., Weiss, Günter
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688458/
https://ncbi.nlm.nih.gov/pubmed/26332507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201545569
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