A critical evaluation of drug delivery from ligand modified nanoparticles: confounding small molecule distribution and efficacy in the central nervous system

In this work, we sought to test how surface modification of poly(lactic-co-glycolic acid) (PLGA) nanoparticles with peptide ligand alters the brain specific delivery of encapsulated molecules. For biodistribution studies, nanoparticles modified with rabies virus glycoprotein (RVG29) were loaded with...

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Publicado en:J Control Release
Main Authors: Cook, Rebecca L., Householder, Kyle T., Chung, Eugene P., Prakapenka, Alesia V., DiPerna, Danielle M., Sirianni, Rachael W.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688251/
https://ncbi.nlm.nih.gov/pubmed/26471392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.10.013
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