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Endoglin is required in Pax3-Derived Cells for Embryonic Blood Vessel Formation
Mutations in endoglin, a TGFβ/BMP coreceptor, are causal for hereditary hemorrhagic telangiectasia (HHT). Endoglin-null (Eng−/−) mouse embryos die at embryonic day (E)10.5-11.5 due to defects in angiogenesis. In part, this is due to an absence of vascular smooth muscle cell differentiation and vesse...
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| Publicado no: | Dev Biol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4688190/ https://ncbi.nlm.nih.gov/pubmed/26481065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2015.10.019 |
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