Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough

Yeast Npl3 is a highly abundant, nuclear-cytoplasmic shuttling, RNA-binding protein, related to metazoan SR proteins. Reported functions of Npl3 include transcription elongation, splicing and RNA 3’ end processing. We used UV crosslinking and analysis of cDNA (CRAC) to map precise RNA binding sites,...

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Bibliografske podrobnosti
izdano v:PLoS Genet
Main Authors: Holmes, Rebecca K., Tuck, Alex C., Zhu, Chenchen, Dunn-Davies, Hywel R., Kudla, Grzegorz, Clauder-Munster, Sandra, Granneman, Sander, Steinmetz, Lars M., Guthrie, Christine, Tollervey, David
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687934/
https://ncbi.nlm.nih.gov/pubmed/26694144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005735
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