Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough

Yeast Npl3 is a highly abundant, nuclear-cytoplasmic shuttling, RNA-binding protein, related to metazoan SR proteins. Reported functions of Npl3 include transcription elongation, splicing and RNA 3’ end processing. We used UV crosslinking and analysis of cDNA (CRAC) to map precise RNA binding sites,...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Holmes, Rebecca K., Tuck, Alex C., Zhu, Chenchen, Dunn-Davies, Hywel R., Kudla, Grzegorz, Clauder-Munster, Sandra, Granneman, Sander, Steinmetz, Lars M., Guthrie, Christine, Tollervey, David
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687934/
https://ncbi.nlm.nih.gov/pubmed/26694144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005735
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