Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough

Yeast Npl3 is a highly abundant, nuclear-cytoplasmic shuttling, RNA-binding protein, related to metazoan SR proteins. Reported functions of Npl3 include transcription elongation, splicing and RNA 3’ end processing. We used UV crosslinking and analysis of cDNA (CRAC) to map precise RNA binding sites,...

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Foilsithe in:PLoS Genet
Main Authors: Holmes, Rebecca K., Tuck, Alex C., Zhu, Chenchen, Dunn-Davies, Hywel R., Kudla, Grzegorz, Clauder-Munster, Sandra, Granneman, Sander, Steinmetz, Lars M., Guthrie, Christine, Tollervey, David
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687934/
https://ncbi.nlm.nih.gov/pubmed/26694144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005735
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