Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough

Yeast Npl3 is a highly abundant, nuclear-cytoplasmic shuttling, RNA-binding protein, related to metazoan SR proteins. Reported functions of Npl3 include transcription elongation, splicing and RNA 3’ end processing. We used UV crosslinking and analysis of cDNA (CRAC) to map precise RNA binding sites,...

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Vydáno v:PLoS Genet
Hlavní autoři: Holmes, Rebecca K., Tuck, Alex C., Zhu, Chenchen, Dunn-Davies, Hywel R., Kudla, Grzegorz, Clauder-Munster, Sandra, Granneman, Sander, Steinmetz, Lars M., Guthrie, Christine, Tollervey, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687934/
https://ncbi.nlm.nih.gov/pubmed/26694144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005735
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