Crucial role of the orexin‐B C‐terminus in the induction of OX(1) receptor‐mediated apoptosis: analysis by alanine scanning, molecular modelling and site‐directed mutagenesis

BACKGROUND AND PURPOSE: Orexins (A and B) are hypothalamic peptides that interact with OX(1) and OX(2) receptors and are involved in the sleep/wake cycle. We previously demonstrated that OX(1) receptors are highly expressed in colon cancer tumours and colonic cancer cell lines where orexins induce a...

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Bibliografiske detaljer
Udgivet i:Br J Pharmacol
Main Authors: Nicole, Pascal, Couvineau, Pierre, Jamin, Nadege, Voisin, Thierry, Couvineau, Alain
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687804/
https://ncbi.nlm.nih.gov/pubmed/26282891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13287
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