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Crucial role of the orexin‐B C‐terminus in the induction of OX(1) receptor‐mediated apoptosis: analysis by alanine scanning, molecular modelling and site‐directed mutagenesis
BACKGROUND AND PURPOSE: Orexins (A and B) are hypothalamic peptides that interact with OX(1) and OX(2) receptors and are involved in the sleep/wake cycle. We previously demonstrated that OX(1) receptors are highly expressed in colon cancer tumours and colonic cancer cell lines where orexins induce a...
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| Publicado no: | Br J Pharmacol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4687804/ https://ncbi.nlm.nih.gov/pubmed/26282891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13287 |
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