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The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations
An organism with a single recessive loss-of-function allele will typically have a wild-type phenotype while individuals homozygous for two copies of the allele will display a mutant phenotype. Here, we develop a method that we refer to as the mutagenic chain reaction (MCR), which is based on the CRI...
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| Pubblicato in: | Science |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4687737/ https://ncbi.nlm.nih.gov/pubmed/25908821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa5945 |
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