Safety and tolerability considerations in the use of sildenafil for children with pulmonary arterial hypertension

Sildenafil is a phosphodiesterase type-5 inhibitor approved for treatment of pulmonary arterial hypertension (PAH) in adults. Data from pediatric trials demonstrate a similar acute safety profile to the adult population but have raised concerns regarding the safety of long-term use in children. Inte...

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Bibliographic Details
Published in:Drug Healthc Patient Saf
Main Authors: Dodgen, Andrew L, Hill, Kevin D
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2015
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687613/
https://ncbi.nlm.nih.gov/pubmed/26719728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DHPS.S65571
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