Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases

Aromatic polyketides make up a large class of natural products with diverse bioactivity. During biosynthesis, linear poly-β-ketone intermediates are regiospecifically cyclized, yielding molecules with defined cyclization patterns that are crucial for polyketide bioactivity. The aromatase/cyclases (A...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Caldara-Festin, Grace, Jackson, David R., Barajas, Jesus F., Valentic, Timothy R., Patel, Avinash B., Aguilar, Stephanie, Nguyen, MyChi, Vo, Michael, Khanna, Avinash, Sasaki, Eita, Liu, Hung-wen, Tsai, Shiou-Chuan
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687605/
https://ncbi.nlm.nih.gov/pubmed/26631750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512976112
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