The introduction of RNA-DNA differences underlies interindividual variation in the human IL12RB1 mRNA repertoire

Human interleukin 12 and interleukin 23 (IL12/23) influence susceptibility or resistance to multiple diseases. However, the reasons underlying individual differences in IL12/23 sensitivity remain poorly understood. Here we report that in human peripheral blood mononuclear cells (PBMCs) and inflamed...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Turner, Amy J., Aggarwal, Praful, Miller, Halli E., Waukau, Jill, Routes, John M., Broeckel, Ulrich, Robinson, Richard T.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687591/
https://ncbi.nlm.nih.gov/pubmed/26621740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515978112
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