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Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage display

Peptide neurotoxins are powerful tools for research, diagnosis, and treatment of disease. Limiting broader use, most receptors lack an identified toxin that binds with high affinity and specificity. This paper describes isolation of toxins for one such orphan target, KcsA, a potassium channel that h...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Zhao, Ruiming, Dai, Hui, Mendelman, Netanel, Cuello, Luis G., Chill, Jordan H., Goldstein, Steve A. N.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687576/
https://ncbi.nlm.nih.gov/pubmed/26627718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514728112
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