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Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant
The dopamine (DA) transporter (DAT) facilitates high-affinity presynaptic DA reuptake that temporally and spatially constrains DA neurotransmission. Aberrant DAT function is implicated in attention-deficit/hyperactivity disorder and autism spectrum disorder. DAT is a major psychostimulant target, an...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4687542/ https://ncbi.nlm.nih.gov/pubmed/26621748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512957112 |
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