Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions

Telomerase helps maintain telomeres by processive synthesis of telomere repeat DNA at their 3′-ends, using an integral telomerase RNA (TER) and telomerase reverse transcriptase (TERT). We report the cryo–electron microscopy structure of Tetrahymena telomerase at ~9 angstrom resolution. In addition t...

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Vydáno v:Science
Hlavní autoři: Jiang, Jiansen, Chan, Henry, Cash, Darian D., Miracco, Edward J., Ogorzalek Loo, Rachel R., Upton, Heather E., Cascio, Duilio, Johnson, Reid O’Brien, Collins, Kathleen, Loo, Joseph A., Zhou, Z. Hong, Feigon, Juli
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687456/
https://ncbi.nlm.nih.gov/pubmed/26472759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab4070
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