The Role of the Carboxyl Terminus Helix C-D Linker in Regulating KCNQ3 K(+) Current Amplitudes by Controlling Channel Trafficking

In the central and peripheral nervous system, the assembly of KCNQ3 with KCNQ2 as mostly heteromers, but also homomers, underlies “M-type” currents, a slowly-activating voltage-gated K(+) current that plays a dominant role in neuronal excitability. KCNQ3 homomers yield much smaller currents compared...

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Udgivet i:PLoS One
Main Authors: Choveau, Frank S., Zhang, Jie, Bierbower, Sonya M., Sharma, Ramaswamy, Shapiro, Mark S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687061/
https://ncbi.nlm.nih.gov/pubmed/26692086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145367
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