Comparative Proteomic Profiling of Ehrlichia ruminantium Pathogenic Strain and Its High-Passaged Attenuated Strain Reveals Virulence and Attenuation-Associated Proteins

The obligate intracellular bacterium Ehrlichia ruminantium (ER) causes heartwater, a fatal tick-borne disease in livestock. In the field, ER strains present different levels of virulence, limiting vaccine efficacy, for which the molecular basis remains unknown. Moreover, there are no genetic tools c...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Marcelino, Isabel, Ventosa, Miguel, Pires, Elisabete, Müller, Markus, Lisacek, Frédérique, Lefrançois, Thierry, Vachiery, Nathalie, Coelho, Ana Varela
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686967/
https://ncbi.nlm.nih.gov/pubmed/26691135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145328
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