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Peptides derived from CXCL8 based on in silico analysis inhibit CXCL8 interactions with its receptor CXCR1

Chemokine CXCL8 is crucial for regulation of inflammatory and immune responses via activating its cognate receptor CXCR1. In this study, molecular docking and binding free energy calculations were combined to predict the initial binding event of CXCL8 to CXCR1 for peptide drug design. The simulation...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jiang, Shinn-Jong, Liou, Je-Wen, Chang, Chun-Chun, Chung, Yi, Lin, Lee-Fong, Hsu, Hao-Jen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686899/
https://ncbi.nlm.nih.gov/pubmed/26689258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18638
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